I even use it on and off. But as I like to keep an eye on everything, I usually turn it all back on. I think the real benefit is what Joel said (and what I've previously said)...it keeps your whats new tab focused purely on topics you want to engage in. My hope was that installing this would increase thread activity as folks would be following only topics they truly want to be a part of. Etc etc.
I can see that if you don't care about politics or health you would want to ignore the immensely popular Trump and virus threads. If you have notifications on, they'd sound like a Price is Right winner bell at times. Ding Ding Ding Ding.