In my experience, its generally a operator error and/or lack of religious maintainance that kills the 6.0
By this statement I can only assume you mean two things either I beat the shit out of it didn't maintain it put to much weight into it or whatever. I'm here to inform you I left the motor stock. I put all new fuel filters (both) the one on the top of he motor and on the fuel rail. I put anti gelling in the tank as required due to the gelling problems. My problem
Was not maintenance it was the faulty stock turbo in which ford decided to get cheap on. There is a part in the turbo that controls the boost based on the rpm of the turbo. Variable geometry turbo the part that makes this turbo work that way well that starts to rust out and get stuck in position. Then at cruising speeds at say 55 mph my turbo decides when I go to pass someone spin up 30lbs of boost instantly. You think I have control over that. I paid 38 grand for a f450 06 back in 2008 with 32000 miles. That truck with my maintenance rituals and trying to baby a construction truck failed before 70 thousand miles. Next move we replaced the heads cold air intake new valve job new heads arp head studs 68 mm turbo new injectors new plugs egr delete sct street tune and 4 inch exhaust. Ok That didn't last either because if you don't upgrade he block at the same time or have it checked with a computer it decided to fail. Well you ask why I didn't do this to begin wih. Well in a power stroke based truck from my year you have to pull the cab. In my case you have to pull a 11 ft utility bed off with a 16 ft utility rack welded to it. So we took our chances. Just to pull he cab and rack by a company who had the means was about 4 grand. So we had a shop do the top end work. Then after that failure I had to find a junkyard motor I found for 4500 with 103 I on the clock pay the company to pull the cab. I pulled the rack off myself at my welders. Paid to have can removed motor installed old motor dismantled and I sold thr parts off of it to eat some costs. Traded the truck in and with in 4 days of trading in the motor went bad and we got a call from a the Chevy dealership.
So wih maintenance about 20 grand and a hell of a lot pita moves I would have to say its a bad motor. On too of that my uncles concrete company ordered brand new fleet of of 10 6.0 trucks and within one year he traded them all in. You may have better luck but by my experiences and views it's a bad motor.
Filters for this thing are 100 bucks a pop as well.