my LS cars always operated with no load above the 180-200 mark, I guess on a cold day the Tstat would open at 160 and give you heat quicker
160 stat would give you worse heat than a 180.
The cooling loop has engine coolant circulate between the block and heater core at all times unless there is a HVAC Bypass valve in there. The stat isn't part of that loop.
So if you move to a 160 stat then the coolant flows the radiator earlier, lowering your highway temps by about 20° and your heater core temps will drop by about the same. 180° is best I think for us. Maybe if we were in a really hot environment then a 160° would be good, but for our area I was never happy with the heat I got when using a 160 in the GTA.
Might give slight benefit with drag racing due to the low heat load, but extended WOT like during a HPDE will heat the coolant well past the 160° mark, probably within the first full lap.